Chikungunya Viruses That Escape Monoclonal Antibody Therapy Are Clinically Attenuated, Stable, and Not Purified in Mosquitoes

Chikungunya virus (CHIKV) is a reemerging mosquito-transmitted alphavirus that causes epidemics of debilitating polyarthritis in humans. A prior study identified two anti-CHIKV monoclonal antibodies ([MAbs] CHK-152 and CHK-166) against the E2 and E1 structural proteins, which had therapeutic efficac...

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Main Authors: Pal, Pankaj, Fox, Julie M., Hawman, David W., Huang, Yan-Jang S., Messaoudi, Ilhem, Kreklywich, Craig, Denton, Michael, Legasse, Alfred W., Smith, Patricia P., Johnson, Syd, Axthelm, Michael K., Vanlandingham, Dana L., Streblow, Daniel N., Higgs, Stephen, Morrison, Thomas E., Diamond, Michael S.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2014
נושאים:
Pathogenesis and Immunity
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135940/
https://ncbi.nlm.nih.gov/pubmed/24829346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01032-14
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