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Characterization of neurosteroid effects on hyperpolarizing current at α4β2δ GABA(A) receptors

RATIONALE: The neurosteroid 3α,5β-THP (3α-OH-5β-pregnan-20-one, pregnanolone) is a modulator of the GABA(A) receptor (GABAR), with α4β2δ GABARs the most sensitive. However, the effects of 3α,5β-THP at α4β2δ are polarity-dependent: 3α,5β-THP potentiates depolarizing current, as has been widely report...

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Sonraí Bibleagrafaíochta
Main Authors: Gong, Qi Hua, Smith, Sheryl S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135043/
https://ncbi.nlm.nih.gov/pubmed/24740493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3538-x
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