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Characterization of neurosteroid effects on hyperpolarizing current at α4β2δ GABA(A) receptors
RATIONALE: The neurosteroid 3α,5β-THP (3α-OH-5β-pregnan-20-one, pregnanolone) is a modulator of the GABA(A) receptor (GABAR), with α4β2δ GABARs the most sensitive. However, the effects of 3α,5β-THP at α4β2δ are polarity-dependent: 3α,5β-THP potentiates depolarizing current, as has been widely report...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4135043/ https://ncbi.nlm.nih.gov/pubmed/24740493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3538-x |
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