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Neurosteroid regulation of GABA(A) receptors: Focus on the α4 and δ subunits

Neurosteroids, such as the progesterone metabolite 3α-OH-5α[β]-pregnan-20-one (THP or [allo]pregnanolone), function as potent positive modulators of the GABA(A) receptor (GABAR) when acutely administered. However, fluctuations in the circulating levels of this steroid at puberty, across endogenous o...

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Bibliografiske detaljer
Main Authors: Smith, Sheryl S., Shen, Hui, Gong, Qi Hua, Zhou, Xiangping
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657726/
https://ncbi.nlm.nih.gov/pubmed/17512983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2007.03.008
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