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Neurosteroid regulation of GABA(A) receptors: Focus on the α4 and δ subunits
Neurosteroids, such as the progesterone metabolite 3α-OH-5α[β]-pregnan-20-one (THP or [allo]pregnanolone), function as potent positive modulators of the GABA(A) receptor (GABAR) when acutely administered. However, fluctuations in the circulating levels of this steroid at puberty, across endogenous o...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657726/ https://ncbi.nlm.nih.gov/pubmed/17512983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2007.03.008 |
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