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Reversal of neurosteroid effects at α4β2δ GABA(A) receptors triggers anxiety at puberty
Puberty is characterized by mood swings and anxiety, often produced by stress. Here, we show that THP (allopregnanolone), a steroid released by stress, increases anxiety in pubertal female mice, a reversal of its well-known anxiety-reducing effect in adults. Anxiety is regulated by GABAergic inhibit...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2007
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1858651/ https://ncbi.nlm.nih.gov/pubmed/17351635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn1868 |
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