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Reversal of neurosteroid effects at α4β2δ GABA(A) receptors triggers anxiety at puberty

Puberty is characterized by mood swings and anxiety, often produced by stress. Here, we show that THP (allopregnanolone), a steroid released by stress, increases anxiety in pubertal female mice, a reversal of its well-known anxiety-reducing effect in adults. Anxiety is regulated by GABAergic inhibit...

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Bibliografiska uppgifter
Huvudupphovsmän: Shen, Hui, Gong, Qi Hua, Aoki, Chiye, Yuan, Maoli, Ruderman, Yevgeniy, Dattilo, Michael, Williams, Keith, Smith, Sheryl S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1858651/
https://ncbi.nlm.nih.gov/pubmed/17351635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn1868
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