Mechanism and consequences of RAF kinase activation by small-molecule inhibitors

Despite the clinical success of RAF inhibitors in BRAF-mutated melanomas, attempts to target RAF kinases in the context of RAS-driven or otherwise RAF wild-type tumours have not only been ineffective, but RAF inhibitors appear to aggravate tumorigenesis in these settings. Subsequent preclinical inve...

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Bibliografische gegevens
Hoofdauteurs: Holderfield, M, Nagel, T E, Stuart, D D
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134487/
https://ncbi.nlm.nih.gov/pubmed/24642617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.139
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