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Mechanism and consequences of RAF kinase activation by small-molecule inhibitors
Despite the clinical success of RAF inhibitors in BRAF-mutated melanomas, attempts to target RAF kinases in the context of RAS-driven or otherwise RAF wild-type tumours have not only been ineffective, but RAF inhibitors appear to aggravate tumorigenesis in these settings. Subsequent preclinical inve...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134487/ https://ncbi.nlm.nih.gov/pubmed/24642617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.139 |
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