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Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors

Protein kinases have emerged as one of the most frequently targeted families of proteins in drug discovery. While the development of small-molecule inhibitors that have the potency and selectivity necessary to be effective cancer drugs is still a formidable challenge, there have been several notable...

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Détails bibliographiques
Auteurs principaux: Krishnamurty, Ratika, Maly, Dustin J.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879594/
https://ncbi.nlm.nih.gov/pubmed/20044834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb9002656
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