Autism-related deficits via dysregulated eIF4E-dependent translational control

Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is postulated to cause Autism Spectrum Disorders (ASD). The mammalian target of rapamycin (mTOR) is strongly implicated in ASD via upstream signaling. However, downstream regulatory mechanisms are ill-defined. We show...

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Hauptverfasser: Gkogkas, Christos G., Khoutorsky, Arkady, Ran, Israeli, Rampakakis, Emmanouil, Nevarko, Tatiana, Weatherill, Daniel B., Vasuta, Cristina, Yee, Stephanie, Truitt, Morgan, Dallaire, Paul, Major, François, Lasko, Paul, Ruggero, Davide, Nader, Karim, Lacaille, Jean-Claude, Sonenberg, Nahum
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133997/
https://ncbi.nlm.nih.gov/pubmed/23172145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11628
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