Autism-related deficits via dysregulated eIF4E-dependent translational control

Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is postulated to cause Autism Spectrum Disorders (ASD). The mammalian target of rapamycin (mTOR) is strongly implicated in ASD via upstream signaling. However, downstream regulatory mechanisms are ill-defined. We show...

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Autores principales: Gkogkas, Christos G., Khoutorsky, Arkady, Ran, Israeli, Rampakakis, Emmanouil, Nevarko, Tatiana, Weatherill, Daniel B., Vasuta, Cristina, Yee, Stephanie, Truitt, Morgan, Dallaire, Paul, Major, François, Lasko, Paul, Ruggero, Davide, Nader, Karim, Lacaille, Jean-Claude, Sonenberg, Nahum
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133997/
https://ncbi.nlm.nih.gov/pubmed/23172145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11628
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