Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

Fragile X syndrome (FXS) is the leading genetic cause of autism. Mutations in Fmr1 (fragile X mental retardation 1 gene) engender exaggerated translation resulting in dendritic spine dysmorphogenesis, synaptic plasticity alterations, and behavioral deficits in mice, which are reminiscent of FXS phen...

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Udgivet i:Cell Rep
Main Authors: Gkogkas, Christos G., Khoutorsky, Arkady, Cao, Ruifeng, Jafarnejad, Seyed Mehdi, Prager-Khoutorsky, Masha, Giannakas, Nikolaos, Kaminari, Archontia, Fragkouli, Apostolia, Nader, Karim, Price, Theodore J., Konicek, Bruce W., Graff, Jeremy R., Tzinia, Athina K., Lacaille, Jean-Claude, Sonenberg, Nahum
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294557/
https://ncbi.nlm.nih.gov/pubmed/25466251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.064
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