Autism-related deficits via dysregulated eIF4E-dependent translational control

Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is postulated to cause Autism Spectrum Disorders (ASD). The mammalian target of rapamycin (mTOR) is strongly implicated in ASD via upstream signaling. However, downstream regulatory mechanisms are ill-defined. We show...

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書誌詳細
主要な著者: Gkogkas, Christos G., Khoutorsky, Arkady, Ran, Israeli, Rampakakis, Emmanouil, Nevarko, Tatiana, Weatherill, Daniel B., Vasuta, Cristina, Yee, Stephanie, Truitt, Morgan, Dallaire, Paul, Major, François, Lasko, Paul, Ruggero, Davide, Nader, Karim, Lacaille, Jean-Claude, Sonenberg, Nahum
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133997/
https://ncbi.nlm.nih.gov/pubmed/23172145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11628
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