Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

Here, we report the analysis of the structure-function relationship of the extracellular region of human interleukin 6 receptor (IL-6R). Upon binding of IL-6, IL-6R becomes associated extracellularly with a non-IL-6-binding but signal transducing molecule, gp130, and the IL-6 signal is generated. In...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Yawata, H, Yasukawa, K, Natsuka, S, Murakami, M, Yamasaki, K, Hibi, M, Taga, T, Kishimoto, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413384/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8467812/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05815.x
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