Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.

Eitemau Tebyg

• Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.
  gan: Murakami, M, et al.
  Cyhoeddwyd: (1991)
• Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.
  gan: Taga, T, et al.
  Cyhoeddwyd: (1992)
• Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.
  gan: Hirota, H, et al.
  Cyhoeddwyd: (1995)
• Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway.
  gan: Thiel, S, et al.
  Cyhoeddwyd: (1998)
• Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
  gan: Yoshida, K, et al.
  Cyhoeddwyd: (1996)