Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

Functional pleiotropy and redundancy are characteristic features of cytokines. To understand the signaling mechanisms of such cytokines, we have proposed a two-chain interleukin (IL) 6 receptor model: IL-6 triggers the association of a ligand-binding chain (IL-6 receptor) and a nonbinding signal tra...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Taga, T, Narazaki, M, Yasukawa, K, Saito, T, Miki, D, Hamaguchi, M, Davis, S, Shoyab, M, Yancopoulos, G D, Kishimoto, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50470/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438305/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.22.10998
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