Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

Functional pleiotropy and redundancy are characteristic features of cytokines. To understand the signaling mechanisms of such cytokines, we have proposed a two-chain interleukin (IL) 6 receptor model: IL-6 triggers the association of a ligand-binding chain (IL-6 receptor) and a nonbinding signal tra...

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Hlavní autoři: Taga, T, Narazaki, M, Yasukawa, K, Saito, T, Miki, D, Hamaguchi, M, Davis, S, Shoyab, M, Yancopoulos, G D, Kishimoto, T
Médium: Artigo
Jazyk:Inglês
Vydáno: 1992
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC50470/
https://ncbi.nlm.nih.gov/pubmed/1438305
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