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When a ribosome encounters a premature termination codon
In mammalian cells, aberrant transcripts harboring a premature termination codon (PTC) can be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation. Truncated polypeptides synthesized from these aberrant transcripts could be toxic to normal cellular functions. However, mamm...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Korean Society for Biochemistry and Molecular Biology
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4133823/ https://ncbi.nlm.nih.gov/pubmed/23351378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2013.46.1.002 |
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