Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

Resting memory CD4(+) T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as suberanilohydroxamic acid (SAHA), romidepsin, and panobinostat have been shown to induce HIV expression in these resting cells. Recently,...

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Hauptverfasser: Jones, Richard Brad, O'Connor, Rachel, Mueller, Stefanie, Foley, Maria, Szeto, Gregory L., Karel, Dan, Lichterfeld, Mathias, Kovacs, Colin, Ostrowski, Mario A., Trocha, Alicja, Irvine, Darrell J., Walker, Bruce D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133386/
https://ncbi.nlm.nih.gov/pubmed/25122219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004287
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