A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4(+) T-Cells to Recognition by Cytotoxic T-Lymphocytes

Resting CD4(+) T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are efficiently cleared by immune effectors. Elimination of this...

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Udgivet i:PLoS Pathog
Main Authors: Jones, R. Brad, Mueller, Stefanie, O’Connor, Rachel, Rimpel, Katherine, Sloan, Derek D., Karel, Dan, Wong, Hing C., Jeng, Emily K., Thomas, Allison S., Whitney, James B., Lim, So-Yon, Kovacs, Colin, Benko, Erika, Karandish, Sara, Huang, Szu-Han, Buzon, Maria J., Lichterfeld, Mathias, Irrinki, Alivelu, Murry, Jeffrey P., Tsai, Angela, Yu, Helen, Geleziunas, Romas, Trocha, Alicja, Ostrowski, Mario A., Irvine, Darrell J., Walker, Bruce D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833318/
https://ncbi.nlm.nih.gov/pubmed/27082643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005545
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