Latent HIV reservoirs exhibit inherent resistance to elimination by CD8(+) T cells

The presence of persistent, latent HIV reservoirs in CD4(+) T cells obstructs current efforts to cure infection. The so-called kick-and-kill paradigm proposes to purge these reservoirs by combining latency-reversing agents with immune effectors such as cytotoxic T lymphocytes. Support for this appro...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Huang, Szu-Han, Ren, Yanqin, Thomas, Allison S., Chan, Dora, Mueller, Stefanie, Ward, Adam R., Patel, Shabnum, Bollard, Catherine M., Cruz, Conrad Russell, Karandish, Sara, Truong, Ronald, Macedo, Amanda B., Bosque, Alberto, Kovacs, Colin, Benko, Erika, Piechocka-Trocha, Alicja, Wong, Hing, Jeng, Emily, Nixon, Douglas F., Ho, Ya-Chi, Siliciano, Robert F., Walker, Bruce D., Jones, R. Brad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785246/
https://ncbi.nlm.nih.gov/pubmed/29355843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97555
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