Latent HIV reservoirs exhibit inherent resistance to elimination by CD8(+) T cells

The presence of persistent, latent HIV reservoirs in CD4(+) T cells obstructs current efforts to cure infection. The so-called kick-and-kill paradigm proposes to purge these reservoirs by combining latency-reversing agents with immune effectors such as cytotoxic T lymphocytes. Support for this appro...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Huang, Szu-Han, Ren, Yanqin, Thomas, Allison S., Chan, Dora, Mueller, Stefanie, Ward, Adam R., Patel, Shabnum, Bollard, Catherine M., Cruz, Conrad Russell, Karandish, Sara, Truong, Ronald, Macedo, Amanda B., Bosque, Alberto, Kovacs, Colin, Benko, Erika, Piechocka-Trocha, Alicja, Wong, Hing, Jeng, Emily, Nixon, Douglas F., Ho, Ya-Chi, Siliciano, Robert F., Walker, Bruce D., Jones, R. Brad
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785246/
https://ncbi.nlm.nih.gov/pubmed/29355843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97555
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