Latent HIV reservoirs exhibit inherent resistance to elimination by CD8(+) T cells

The presence of persistent, latent HIV reservoirs in CD4(+) T cells obstructs current efforts to cure infection. The so-called kick-and-kill paradigm proposes to purge these reservoirs by combining latency-reversing agents with immune effectors such as cytotoxic T lymphocytes. Support for this appro...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Huang, Szu-Han, Ren, Yanqin, Thomas, Allison S., Chan, Dora, Mueller, Stefanie, Ward, Adam R., Patel, Shabnum, Bollard, Catherine M., Cruz, Conrad Russell, Karandish, Sara, Truong, Ronald, Macedo, Amanda B., Bosque, Alberto, Kovacs, Colin, Benko, Erika, Piechocka-Trocha, Alicja, Wong, Hing, Jeng, Emily, Nixon, Douglas F., Ho, Ya-Chi, Siliciano, Robert F., Walker, Bruce D., Jones, R. Brad
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785246/
https://ncbi.nlm.nih.gov/pubmed/29355843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97555
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