BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo

Curing HIV infection will require the elimination of a reservoir of infected CD4(+) T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir...

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發表在:J Clin Invest
Main Authors: Ren, Yanqin, Huang, Szu Han, Patel, Shabnum, Alberto, Winiffer D. Conce, Magat, Dean, Ahimovic, Dughan, Macedo, Amanda B., Durga, Ryan, Chan, Dora, Zale, Elizabeth, Mota, Talia M., Truong, Ronald, Rohwetter, Thomas, McCann, Chase D., Kovacs, Colin M., Benko, Erika, Wimpelberg, Avery, Cannon, Christopher, Hardy, W. David, Bosque, Alberto, Bollard, Catherine M., Jones, R. Brad
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2020
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191002/
https://ncbi.nlm.nih.gov/pubmed/32027622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132374
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