BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo

Curing HIV infection will require the elimination of a reservoir of infected CD4(+) T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ren, Yanqin, Huang, Szu Han, Patel, Shabnum, Alberto, Winiffer D. Conce, Magat, Dean, Ahimovic, Dughan, Macedo, Amanda B., Durga, Ryan, Chan, Dora, Zale, Elizabeth, Mota, Talia M., Truong, Ronald, Rohwetter, Thomas, McCann, Chase D., Kovacs, Colin M., Benko, Erika, Wimpelberg, Avery, Cannon, Christopher, Hardy, W. David, Bosque, Alberto, Bollard, Catherine M., Jones, R. Brad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191002/
https://ncbi.nlm.nih.gov/pubmed/32027622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132374
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