BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo

Curing HIV infection will require the elimination of a reservoir of infected CD4(+) T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Ren, Yanqin, Huang, Szu Han, Patel, Shabnum, Alberto, Winiffer D. Conce, Magat, Dean, Ahimovic, Dughan, Macedo, Amanda B., Durga, Ryan, Chan, Dora, Zale, Elizabeth, Mota, Talia M., Truong, Ronald, Rohwetter, Thomas, McCann, Chase D., Kovacs, Colin M., Benko, Erika, Wimpelberg, Avery, Cannon, Christopher, Hardy, W. David, Bosque, Alberto, Bollard, Catherine M., Jones, R. Brad
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191002/
https://ncbi.nlm.nih.gov/pubmed/32027622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132374
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