Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8(+) T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase Inhibitors during HIV-1 Latency Reversal

Clinical trials investigating histone deacetylase inhibitors (HDACi) to reverse HIV-1 latency aim to expose reservoirs in antiretroviral (ARV)-treated individuals to clearance by immune effectors, yet have not driven measurable reductions in the frequencies of infected cells. We therefore investigat...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Mota, Talia M., McCann, Chase D., Danesh, Ali, Huang, Szu-Han, Magat, Dean B., Ren, Yanqin, Leyre, Louise, Bui, Tracy D., Rohwetter, Thomas M., Kovacs, Colin M., Benko, Erika, MacLaren, Lynsay, Wimpelberg, Avery, Cannon, Christopher M., Hardy, W. David, Safrit, Jeffrey T., Jones, R. Brad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163115/
https://ncbi.nlm.nih.gov/pubmed/32051267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01845-19
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