Latent HIV reservoirs exhibit inherent resistance to elimination by CD8(+) T cells

The presence of persistent, latent HIV reservoirs in CD4(+) T cells obstructs current efforts to cure infection. The so-called kick-and-kill paradigm proposes to purge these reservoirs by combining latency-reversing agents with immune effectors such as cytotoxic T lymphocytes. Support for this appro...

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Publicado en:J Clin Invest
Autores principales: Huang, Szu-Han, Ren, Yanqin, Thomas, Allison S., Chan, Dora, Mueller, Stefanie, Ward, Adam R., Patel, Shabnum, Bollard, Catherine M., Cruz, Conrad Russell, Karandish, Sara, Truong, Ronald, Macedo, Amanda B., Bosque, Alberto, Kovacs, Colin, Benko, Erika, Piechocka-Trocha, Alicja, Wong, Hing, Jeng, Emily, Nixon, Douglas F., Ho, Ya-Chi, Siliciano, Robert F., Walker, Bruce D., Jones, R. Brad
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785246/
https://ncbi.nlm.nih.gov/pubmed/29355843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97555
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