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Design and Synthesis of Potent Macrocyclic HIV-1 Protease Inhibitors Involving P1-P2 Ligands
A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized. The compounds incorporated 16- to 19-membered macrocyclic rings between a Nelfinavir-like P2 ligand and a tyrosine side chain containing a hydroxyethylamine sulfonamide isostere. All cyclic inhibitors are mo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4133278/ https://ncbi.nlm.nih.gov/pubmed/25050776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4ob00738g |
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