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Design and Synthesis of Potent Macrocyclic HIV-1 Protease Inhibitors Involving P1-P2 Ligands

A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized. The compounds incorporated 16- to 19-membered macrocyclic rings between a Nelfinavir-like P2 ligand and a tyrosine side chain containing a hydroxyethylamine sulfonamide isostere. All cyclic inhibitors are mo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ghosh, Arun K., Schiltz, Gary E., Rusere, Linah N., Osswald, Heather L., Walters, D. Eric, Amano, Masayuki, Mitsuya, Hiroaki
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133278/
https://ncbi.nlm.nih.gov/pubmed/25050776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4ob00738g
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