Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain

DNA topoisomerase II (topo II) changes DNA topology by cleavage/re-ligation cycle(s) and thus contributes to various nuclear DNA transactions. It is largely unknown how the enzyme is controlled in a nuclear context. Several studies have suggested that its C-terminal domain (CTD), which is dispensabl...

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Bibliographische Detailangaben
Hauptverfasser: Onoda, Akihisa, Hosoya, Osamu, Sano, Kuniaki, Kiyama, Kazuko, Kimura, Hiroshi, Kawano, Shinji, Furuta, Ryohei, Miyaji, Mary, Tsutsui, Ken, Tsutsui, Kimiko M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132749/
https://ncbi.nlm.nih.gov/pubmed/25034690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku640
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