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Engineered Hyperactive Integrase for Concerted HIV-1 DNA Integration
The DNA cutting and joining reactions of HIV-1 integration are catalyzed by integrase (IN), a viral protein that functions as a tetramer bridging the two viral DNA ends (intasome). Two major obstacles for biochemical and structural studies of HIV-1 intasomes are 1) the low efficiency of assembly wit...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132020/ https://ncbi.nlm.nih.gov/pubmed/25119883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105078 |
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