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A peptide derived from lens epithelium-derived growth factor stimulates HIV-1 DNA integration and facilitates intasome structural studies

The low solubility and aggregation properties of HIV-1 integrase are major obstacles for biochemical and structural studies. Lens epithelium-derived growth factor (LEDGF) is a cellular factor that binds integrase and tethers preintegration complexes to chromatin prior to integration. LEDGF also stim...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Li, Min, Chen, Xuemin, Wang, Huaibin, Jurado, Kellie A, Engelman, Alan N., Craigie, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350280/
https://ncbi.nlm.nih.gov/pubmed/32061936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.01.040
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