Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

Lens epithelium-derived growth factor (LEDGF) fusion proteins can direct HIV-1 DNA integration to novel sites in the host genome. The C terminus of LEDGF contains an integrase binding domain (IBD), and the N terminus binds chromatin. LEDGF normally directs integrations to the bodies of expressed gen...

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Detalhes bibliográficos
Main Authors: Ferris, Andrea L., Wu, Xiaolin, Hughes, Christina M., Stewart, Claudia, Smith, Steven J., Milne, Thomas A., Wang, Gang G., Shun, Ming-Chieh, Allis, C. David, Engelman, Alan, Hughes, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840313/
https://ncbi.nlm.nih.gov/pubmed/20133638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914142107
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