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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their enzymatic activities and chromosomal association. A novel genetic knockout model was established that allowed us for the first time to analyze HIV-1 integration in the absence of LEDGF/p75 protein. Supporting a cr...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1920171/ https://ncbi.nlm.nih.gov/pubmed/17639082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1565107 |
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