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Lys-34, Dispensable for Integrase Catalysis, Is Required for Preintegration Complex Function and Human Immunodeficiency Virus Type 1 Replication

Retroviral integrases (INs) function in the context of preintegration complexes (PICs). Two conserved Lys residues in the N-terminal domain of human immunodeficiency virus type 1 (HIV-1) IN were analyzed here for their roles in integration and virus replication. Whereas HIV-1(K46A) grew like the wil...

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Bibliografske podrobnosti
Main Authors: Lu, Richard, Vandegraaff, Nick, Cherepanov, Peter, Engelman, Alan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1211547/
https://ncbi.nlm.nih.gov/pubmed/16160186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.19.12584-12591.2005
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