Recombinant Human Immunodeficiency Virus Type 1 Integrase Exhibits a Capacity for Full-Site Integration In Vitro That Is Comparable to That of Purified Preintegration Complexes from Virus-Infected Cells

Retrovirus preintegration complexes (PIC) in virus-infected cells contain the linear viral DNA genome (∼10 kbp), viral proteins including integrase (IN), and cellular proteins. After transport of the PIC into the nucleus, IN catalyzes the concerted insertion of the two viral DNA ends into the host c...

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Bibliografiska uppgifter
Huvudupphovsmän: Sinha, Sapna, Grandgenett, Duane P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2005
Ämnen:
Genome Replication and Regulation of Viral Gene Expression
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143728/
https://ncbi.nlm.nih.gov/pubmed/15956566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.13.8208-8216.2005
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