Efficient Concerted Integration by Recombinant Human Immunodeficiency Virus Type 1 Integrase without Cellular or Viral Cofactors

Replication of retroviruses requires integration of the linear viral DNA genome into the host chromosomes. Integration requires the viral integrase (IN), located in high-molecular-weight nucleoprotein complexes termed preintegration complexes (PIC). The PIC inserts the two viral DNA termini in a con...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Sinha, Sapna, Pursley, Michael H., Grandgenett, Duane P.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2002
Fag:	Replication
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136053/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11884535/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.7.3105-3113.2002
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