Efficient Concerted Integration by Recombinant Human Immunodeficiency Virus Type 1 Integrase without Cellular or Viral Cofactors

Replication of retroviruses requires integration of the linear viral DNA genome into the host chromosomes. Integration requires the viral integrase (IN), located in high-molecular-weight nucleoprotein complexes termed preintegration complexes (PIC). The PIC inserts the two viral DNA termini in a con...

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Autori principali: Sinha, Sapna, Pursley, Michael H., Grandgenett, Duane P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC136053/
https://ncbi.nlm.nih.gov/pubmed/11884535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.7.3105-3113.2002
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