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LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: Implications for the mechanism of viral cDNA integration
An integrase dimer can process and integrate a single HIV-1 DNA end in vitro, whereas a tetramer is required to integrate two ends. LEDGF/p75 can potently stimulate integrase activity, but its affects on half- versus full-site integration have not been investigated. Stimulation of half-site but inhi...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1864956/ https://ncbi.nlm.nih.gov/pubmed/17258258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.12.022 |
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