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Outer domains of integrase within retroviral intasomes are dispensible for catalysis of DNA integration
Retroviral DNA integration is mediated by nucleoprotein complexes (intasomes) comprising a pair of viral DNA ends synapsed by a tetramer of integrase. Current integrase inhibitors act on intasomes rather than free integrase protein. Structural and functional studies of intasomes are essential to und...
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| Udgivet i: | Protein Sci |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4815351/ https://ncbi.nlm.nih.gov/pubmed/26537415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2837 |
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