Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.

Transgenes linked to the beta-globin locus control region (LCR) are transcribed in a copy-dependent manner that is independent of the integration site. It has previously been shown that the LCR 5'HS2 region does not require its NF-E2 dimer binding site for LCR activity. In this paper we analyse...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Ellis, J, Talbot, D, Dillon, N, Grosveld, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413182/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8428573/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05638.x
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