A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.

The beta-globin gene complex is regulated by an upstream locus control region (LCR) which is responsible for high-level, position-independent, erythroid-cell-specific expression of the genes in the cluster. Its role in the developmental regulation of beta-like globin gene transcription remains to be...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Morley, B J, Abbott, C A, Sharpe, J A, Lida, J, Chan-Thomas, P S, Wood, W G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364377/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1373805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.5.2057-2066.1992
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