A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.
The beta-globin gene complex is regulated by an upstream locus control region (LCR) which is responsible for high-level, position-independent, erythroid-cell-specific expression of the genes in the cluster. Its role in the developmental regulation of beta-like globin gene transcription remains to be...
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| Published in: | Mol Cell Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
1992
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364377/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1373805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.5.2057-2066.1992 |
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