A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.

Single-copy human beta-globin transgenes are very susceptible to suppression by position effects of surrounding closed chromatin. However, these position effects are overcome by a 20 kbp DNA fragment containing the locus control region (LCR). Here we show that the 6.5 kbp microlocus LCR cassette rep...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ellis, J, Tan-Un, K C, Harper, A, Michalovich, D, Yannoutsos, N, Philipsen, S, Grosveld, F
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC449974/
https://ncbi.nlm.nih.gov/pubmed/8599939
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