A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.

Single-copy human beta-globin transgenes are very susceptible to suppression by position effects of surrounding closed chromatin. However, these position effects are overcome by a 20 kbp DNA fragment containing the locus control region (LCR). Here we show that the 6.5 kbp microlocus LCR cassette rep...

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Pubblicato in:	EMBO J
Autori principali:	Ellis, J, Tan-Un, K C, Harper, A, Michalovich, D, Yannoutsos, N, Philipsen, S, Grosveld, F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449974/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8599939/
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