The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.

Proper expression of the human beta-like globin genes is completely dependent on the presence of the locus control region or LCR, a region containing four DNase hypersensitive sites (HS1-4) situated 5' to the structural genes. Linkage of the LCR to a transgene results in copy number-dependent transc...

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Pubblicato in:	EMBO J
Autori principali:	Philipsen, S, Pruzina, S, Grosveld, F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413309/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8458325/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05749.x
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