Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

Megazol (7) is a 5-nitroimidazole that is highly active against Trypanosoma cruzi and Trypanosoma brucei, as well as drug-resistant forms of trypanosomiasis. Compound 7 is not used clinically due to its mutagenic and genotoxic properties, but has been largely used as a lead compound. Here, we compar...

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Detalhes bibliográficos
Main Authors: de Carvalho, Alcione Silva, Salomão, Kelly, de Castro, Solange Lisboa, Conde, Taline Ramos, Zamith, Helena Pereira da Silva, Caffarena, Ernesto Raúl, Hall, Belinda Suzette, Wilkinson, Shane Robert, Boechat, Núbia
Formato: Artigo
Idioma:Inglês
Publicado em: Instituto Oswaldo Cruz, Ministério da Saúde 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131783/
https://ncbi.nlm.nih.gov/pubmed/24676659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-0276140497
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