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Activity of Megazol, a Trypanocidal Nitroimidazole, Is Associated with DNA Damage
DNA damage associated with the trypanocidal activity of megazol [2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole] was shown in experiments in which DNA repair-deficient RAD51(−/−) Trypanosoma brucei mutants were found to be hypersensitive to the drug. Parasites resistant to megazol were...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Microbiology
2003
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC201145/ https://ncbi.nlm.nih.gov/pubmed/14506061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.10.3368-3370.2003 |
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