Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group

Nitroimidazoles exhibit high microbicidal activity, but mutagenic, genotoxic and cytotoxic properties have been attributed to the presence of the nitro group. However, we synthesised nitroimidazoles with activity against the trypomastigotes of Trypanosoma cruzi, but that were not genotoxic. Herein,...

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Xehetasun bibliografikoak
Argitaratua izan da:Mem Inst Oswaldo Cruz
Egile Nagusiak: Boechat, Núbia, Carvalho, Alcione S, Salomão, Kelly, de Castro, Solange L, Araujo-Lima, Carlos F, Mello, Francisco VC, Felzenszwalb, Israel, Aiub, Claudia AF, Conde, Taline Ramos, Zamith, Helena PS, Skupin, Rolf, Haufe, Günter
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Instituto Oswaldo Cruz, Ministério da Saúde 2015
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501412/
https://ncbi.nlm.nih.gov/pubmed/26018452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760140248
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