β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons

Despite advances in understanding the signaling mechanisms involved in the development and maintenance of chronic pain, the pharmacologic treatment of chronic pain has seen little advancement. Agonists at the mu opioid receptor (MOPr) continue to be vital in the treatment of many forms of chronic pa...

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Bibliografiske detaljer
Main Authors: Rowan, Matthew P, Szteyn, Kalina, Doyle, Allison P, Gomez, Ruben, Henry, Michael A, Jeske, Nathaniel A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131480/
https://ncbi.nlm.nih.gov/pubmed/25085415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-10-50
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