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β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1
FFAR1/GPR40 is a seven-transmembrane domain receptor (7TMR) expressed in pancreatic β cells and activated by FFAs. Pharmacological activation of GPR40 is a strategy under consideration to increase insulin secretion in type 2 diabetes. GPR40 is known to signal predominantly via the heterotrimeric G p...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4543669/ https://ncbi.nlm.nih.gov/pubmed/26157145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644450 |
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