β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1

FFAR1/GPR40 is a seven-transmembrane domain receptor (7TMR) expressed in pancreatic β cells and activated by FFAs. Pharmacological activation of GPR40 is a strategy under consideration to increase insulin secretion in type 2 diabetes. GPR40 is known to signal predominantly via the heterotrimeric G p...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Mancini, Arturo D., Bertrand, Gyslaine, Vivot, Kevin, Carpentier, Éric, Tremblay, Caroline, Ghislain, Julien, Bouvier, Michel, Poitout, Vincent
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543669/
https://ncbi.nlm.nih.gov/pubmed/26157145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.644450
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