Inhibition of MMP-2 Expression with siRNA Increases Baseline Cardiomyocyte Contractility and Protects against Simulated Ischemic Reperfusion Injury

Matrix metalloproteinases (MMPs) significantly contribute to ischemia reperfusion (I/R) injury, namely, by the degradation of contractile proteins. However, due to the experimental models adopted and lack of isoform specificity of MMP inhibitors, the cellular source and identity of the MMP(s) involv...

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Bibliographische Detailangaben
Hauptverfasser: Lin, Han-Bin, Cadete, Virgilio J. J., Sra, Bikramjit, Sawicka, Jolanta, Chen, Zhicheng, Bekar, Lane K., Cayabyab, Francisco, Sawicki, Grzegorz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131446/
https://ncbi.nlm.nih.gov/pubmed/25147815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/810371
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