Combined subthreshold dose inhibition of myosin light chain phosphorylation and MMP-2 activity provides cardioprotection from ischaemic/reperfusion injury in isolated rat heart

BACKGROUND AND PURPOSE: Phosphorylation and degradation of myosin light chain 1 (MLC1) during myocardial ischaemia/reperfusion (I/R) injury is a well-established phenomenon. It has been established that MMP-2 is involved in MLC1 degradation and that this degradation is increased when MLC1 is phospho...

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Detalhes bibliográficos
Main Authors: Cadete, Virgilio J J, Sawicka, Jolanta, Bekar, Lane K, Sawicki, Grzegorz
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834761/
https://ncbi.nlm.nih.gov/pubmed/23822644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12289
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