Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-renewal of Stem Cells

Our understanding of how stem cells are regulated to maintain appropriate tissue size and architecture is incomplete. We show that Yap is required for the actual maintenance of an adult mammalian stem cell. Without Yap, adult airway basal stem cells are lost through their unrestrained differentiatio...

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Autores principales: Zhao, Rui, Fallon, Timothy R., Saladi, Srinivas Vinod, Pardo-Saganta, Ana, Villoria, Jorge, Mou, Hongmei, Vinarsky, Vladimir, Gonzalez-Celeiro, Meryem, Nunna, Naveen, Hariri, Lida P., Camargo, Fernando, Ellisen, Leif W., Rajagopal, Jayaraj
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130488/
https://ncbi.nlm.nih.gov/pubmed/25043474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.06.004
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