ACTL6A is co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation and Poor Prognosis

Loss-of-function mutations in SWI/SNF chromatin remodeling subunit genes are observed in many cancers, but an oncogenic role for SWI/SNF is not well established. Here we reveal that ACTL6A, encoding a SWI/SNF subunit linked to stem and progenitor cell function, is frequently co-amplified and highly...

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Publicat a:Cancer Cell
Autors principals: Saladi, Srinivas V., Ross, Kenneth, Karaayvaz, Mihriban, Tata, Purushothama R., Mou, Hongmei, Rajagopal, Jayaraj, Ramaswamy, Sridhar, Ellisen, Leif W.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225026/
https://ncbi.nlm.nih.gov/pubmed/28041841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.12.001
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