Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-renewal of Stem Cells

Our understanding of how stem cells are regulated to maintain appropriate tissue size and architecture is incomplete. We show that Yap is required for the actual maintenance of an adult mammalian stem cell. Without Yap, adult airway basal stem cells are lost through their unrestrained differentiatio...

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Bibliografiske detaljer
Main Authors: Zhao, Rui, Fallon, Timothy R., Saladi, Srinivas Vinod, Pardo-Saganta, Ana, Villoria, Jorge, Mou, Hongmei, Vinarsky, Vladimir, Gonzalez-Celeiro, Meryem, Nunna, Naveen, Hariri, Lida P., Camargo, Fernando, Ellisen, Leif W., Rajagopal, Jayaraj
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130488/
https://ncbi.nlm.nih.gov/pubmed/25043474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.06.004
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